23 Semaglutide Clinics in South Dakota
Review Semaglutide clinics in South Dakota, including providers offering Ozempic, Wegovy, and Rybelsus for weight loss. Each listing shows rating, medication availability, telehealth options, and provider contact details so you can compare before booking.
How listings are built
Data is compiled from Google Business Profiles and clinic websites using automated research tools. Medication confirmed means medication names were found on the clinic's own website. Claimed means the clinic owner actively manages this page and has verified their details. Fields labeled “owner-provided” were updated directly by the practice.
Rankings on directory pages are based on Google rating, data completeness, and review count. Paid placement is always labeled Sponsored and does not affect organic rankings. Full methodology →
Cities with Semaglutide providers in South Dakota
All Semaglutide clinics in South Dakota
Sponsored listings may appear first in default sorting. Ratings, reviews, and medication data are not affected by paid placement. How rankings work
What the badges mean
Full ranking methodology → • Pricing and medications can change. Always confirm with the clinic directly.
Remedy 605
LIVE Hydration Spa Sioux Falls
Refined Aesthetics
Encompass Wellness & Aesthetics
Cicily's Aesthetics
Nutrishop
Novo Aesthetics
Black Hills IV Wellness Spa
The Confidence Collective
Gameday Men's Health Sioux Falls TRT, Peptide, and ED Clinic
Era Health
Monument Health Rapid City Clinic, Flormann Street
Monument Health General Surgery and Bariatrics
Health Concepts
EVOLVE Strength & Nutrition Coaching
Sioux Falls Hypnosis
Pure Medical Aesthetics, PLLC
Trillion Health and Hormone Clinic
Accelerate Wellness - Longevity Medicine Clinic
Limitless Male Medical Clinic
Integrated Women's Health
What to look for in a Semaglutide clinic
- Brand versus compounded. Some clinics offer brand Ozempic, Wegovy, Rybelsus; others offer compounded Semaglutide. Ask which one. The cost, oversight, and experience differ.
- Dose titration plan. Semaglutide is titrated up over weeks. Confirm the clinic handles dose increases without extra visit fees.
- Insurance versus cash pay. Brand coverage depends on your plan and indication. Compounded Semaglutide is usually cash pay.
- Follow-up and monitoring. Ask what labs, weigh-ins, or check-ins are included in the monthly program.
About Semaglutide in South Dakota
What is Semaglutide?
Semaglutide is the active ingredient in Ozempic, Wegovy, and Rybelsus. It works by copying a natural hunger hormone called GLP-1, which tells your brain you are full and slows digestion. Novo Nordisk originally developed it for type 2 diabetes (Ozempic, 2017), then got it approved at a higher dose for weight loss (Wegovy, 2021). In March 2026, an even higher dose called Wegovy HD was approved. Semaglutide is the most widely prescribed GLP-1 medication in the world, with clinical trials showing 15 to 17% average body weight loss.
Brand names
Semaglutide is available as Ozempic, Wegovy, Rybelsus, manufactured by Novo Nordisk.
Expected weight loss
In the main weight loss trial, people on Wegovy 2.4 mg lost about 14.9% of their body weight over 68 weeks (about 16 months). About one in three lost 20% or more. For a 200-pound person, 15% is roughly 30 pounds. Results vary from person to person depending on dose, diet, exercise, and how your body responds.
Cost in South Dakota
Without insurance, Semaglutide typically costs $800-$1,200/month (Ozempic), $1,300-$1,400/month (Wegovy). With insurance, costs range from $25-$200/month (varies by plan). Compounded options may be available at $200-$500/month.
Savings programs: Novo Nordisk offers savings cards for eligible commercially insured patients. NovoCare patient assistance program available for uninsured/underinsured patients.
Frequently asked questions
There are 23 clinics prescribing Semaglutide (Ozempic and Wegovy and Rybelsus) in South Dakota. South Dakota is one of the better-served states for Semaglutide availability.
Yes, 19 of 23 Semaglutide providers in South Dakota (83%) offer telehealth. Most providers here support virtual visits, so you can start treatment without an office visit.
Brand-name Ozempic and Wegovy and Rybelsus costs $800–$1,400/month without insurance in South Dakota. Compounded Semaglutide from clinic weight loss programs typically runs $200–$500/month. With insurance, copays range from $25–$200/month depending on your plan's formulary and whether prior authorization is required.
Yes. Semaglutide is a prescription medication in all US states including South Dakota. You can get evaluated and prescribed through 19 telehealth providers in South Dakota, or visit any of the 23 clinics listed here in person.
Coverage depends on your plan and diagnosis. Semaglutide is widely covered for type 2 diabetes. For weight management, coverage is expanding. Wegovy and Zepbound now have broader approval, but many plans still require prior authorization or documented BMI criteria. Check with your insurer or ask the clinic to verify coverage before your appointment.
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